For me, it’s the Big Bang Theory, a show I enjoyed somewhere after it’s first season, and which I watched for about two or three season before it’s many problems started to be too much for me to overlook!. The biggest problem though is thst the four primary characters became utterly unlikable! I only hated Howard at first, and then Leonard’s passivity started to get on my nerves, then Sheldon’s compete buttholery put the final nail in that.

When it gets to the point where a generally nonviolent person like me is imagining cheerfully slapping the sh** out of a characters face, it’s well past time to stop watching the show.

Come to think of it, that’s the main reason I usually stop watching some shows, (including a couple you mentioned) and I’m wholly unwilling to sit any longer with characters I just don’t like.